Prof. Richmond Sarpong, University of California, Berkeley, USA

Break-it-to-Make-it Strategies for Chemical Synthesis Inspired by Complex Natural Products

Natural products continue to inspire and serve as the basis of new medicines. They also provide intricate problems that expose limitations in the strategies and methods employed in chemical synthesis. Several strategies and methods that have been developed in our laboratory and applied to the syntheses of architecturally complex natural products will be discussed. In particular, new ways to employ C–C bond cleavage (i.e., break-it-to-make-it strategies) in complex molecule synthesis will be presented.