Prof. Dr. Dirk Trauner, New York University, USA

Making Molecules to Modulate Neural Systems

Start Date 02.11.2021 - 17:00
Event End 02.11.2021 - 18:00
Location University of Zurich, Department of Chemistry
Lecture Hall Y03-G-03

Tetrodotoxin is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, and one of the most celebrated targets of synthetic chemistry. I will present a stereoselective synthesis of TTX that proceeds in 21 steps and can deliver the molecule, and derivatives thereof, on an unprecedented scale. In addition, I will discuss a new class of compounds that enable optical control of synaptic function. These photoactivatable PROTACs (“PHOTACs”) could found widespread use in memory research.