The journal is included in major indexing media such as BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, EMBASE/Excerpta Medica, etc. In addition to publishing regular review articles, the journal also publishes full-length or mini- ‘Hot Topic’ thematic issues that are guest-edited by leading scientists in their areas of research emphasis. The number of contributions in each thematic issue may vary from 6 to 10 articles for a full-length Hot Topic issue and 3 to 5 manuscripts for a mini- Hot Topic Issue. Thematic issues are particularly widely-read and cited. I am writing to invite you to consider submitting a proposal for a theme issue. Your proposal should contain a 250-word Aims and Scope statement, your curriculum vitae and bibliography, a list of possible contributing authors and their institutional affiliations, the titles of the proposed papers and a tentative deadline for submission of the complete set of manuscripts. It is recommended that only very eminent contributing authors are selected from different regions, with the majority being from technologically advanced countries. Please submit your thematic issue proposals to for the Editor-in-Chief’s review and approval. Forthcoming Guest-Edited Issues and Most Cited Articles are available on the journal’s web site Guest Editors of thematic issues will receive a free online subscription to the journal for one year, whereas all main contributing authors will receive five free e-reprints of their published paper. Multiple issues are available to Guest Editors and contributing authors at discounted rates. In case you find the task of Guest Editing a complete issue onerous, you may also wish to consider submitting a proposal for a single article online via All submitted proposals and manuscripts will be peer-reviewed prior to a possible decision on acceptance for publication. We eagerly look forward to receiving your positive response in this regard. Yours sincerely, Co-Editors-in-Chief, MRMC Prof. Atta-ur-Rahman, FRS University of Cambridge Dr. M. Iqbal Choudhry University of Karachi